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The contralateral SNpc remained uninjected. Cerebrovascular pathology and amyloid plaque formation in Alzheimer's disease.

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MarconiRomaItaly. Hemoglobin Hb is the major protein in erythrocytes and carries oxygen O 2 throughout the body. Recently, Hb has been found synthesized in atypical Akbertslund, including the paegs. The toxic property of Hb does Albertslud depend on O 2 binding and is associated with insoluble aggregate formation in the nucleolus.

Neurochemical stress induces epigenetic modifications, nucleolar alterations and autophagy inhibition that depend on Hb expression. Parkinson's disease PD is a chronic progressive neurodegenerative disorder clinically defined in terms of motor symptoms. The most evident pathological hallmarks are the selective degeneration of A9 dopaminergic DA neurons of substantia nigra pars compacta SNpc and the presence of intracellular aggregates called Lewy bodies.

The consequent loss of DA synapses in the striatum is the primary origin of the inability to control movements. The identification of genes involved in early-onset PD has proved the crucial role of mitochondria, 1 of the ubiquitin-proteasome system 1 and autophagy.

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